Innate immunity acquired at birth presents is considered the first line of defense and includes an entire army of cells like epithelial cells, macrophages, NK, plasma proteins complements and cytokines. It was found that this immunity changes with aging and the ability to phagocytose pathogens decreases and this leads to inability to fight tumors. Natural Killer (NK) is part of the innate immune system that fights infected and malignant cells. Stimulating NK is being investigated for cancer prevention treatments. How can we better activate the NK cells and stimulate innate immunity? Studies suggest that resveratrol could activate NK cells. Resveratrol (tans 3,4,4 trihydroxystilbene) can be found in many plants including grapes, berries, tomatoes and has been attributed anti cancerous properties. The mechanism of action is through suppression of NF-kappaB, JNK, MAPK, Akt, PKC, PKD and down regulates COX-2, VEGF, IL-1, IL-6, IL-8, 5-LOX.
Other studies suggest resveratrol suppresses the STAT3 and inhibits JAK2 phosphorylation, and downregulates anti apoptotic proteins MCL1. Another studied effect of Resveratrol is that modulates sphingolipid metabolism. The benefic effect of Resveratrol has been considered as a support therapy even when employing conventional therapy like chemotherapy.
PLoS One. 2013;8(1):e55183. doi: 10.1371/journal.pone.0055183. Epub 2013 Jan 25.
Resveratrol induces cell cycle arrest and apoptosis in malignant NK cells via JAK2/STAT3 pathway inhibition.Quoc Trung L1, Espinoza JL, Takami A, Nakao S. Retrieved from:https://www.ncbi.nlm.nih.gov/pubmed/?term=Resveratrol+induces+cell+cycle+arrest+and+apoptosis+in+maligna
Arch Toxicol. 2014 Dec;88(12):2213-32. doi: 10.1007/s00204-014-1386-4. Epub 2014 Oct 25.
Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.
Lim KG1, Gray AI, Anthony NG, Mackay SP, Pyne S, Pyne NJ. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/?term=Resveratrol+and+its+oligomers%3A+modulation+of+sphingolipid
Cancer Detect Prev. 2006;30(3):217-23. Epub 2006 Jul 26. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Fulda S1, Debatin KM. Retrieved from:https://www.ncbi.nlm.nih.gov/pubmed/?term=Resveratrol+modulation+of+signal+transduction+in+apoptosis+and+cell+survival%3A+a+mini-review
Nutr J. 2016 May 4;15(1):47. doi: 10.1186/s12937-016-0167-8. Nutritional immunology: function of natural killer cells and their modulation by resveratrol for cancer prevention and treatment .Leischner C1, Burkard M1,2, Pfeiffer MM3, Lauer UM1, Busch C2,4, Venturelli Retrieved from:https://www.ncbi.nlm.nih.gov/pubmed/?term=Nutritional+immunology%3A+function+of+natural+killer+cel